Efeitos nefroprotetores de Eleutherine Americana Merr contra a citotoxicidade induzida por acetato de chumbo em camundongos BALB/C
DOI:
https://doi.org/10.5935/jetia.v9i40.855Resumo
O chumbo é um metal venenoso, prejudicial à maioria dos órgãos do corpo humano se a exposição ultrapassar um nível permitido de 50 µg/m3 e um nível de ação de 30 µg/m3. Isso ocorre através da iniciação de espécies reativas de oxigênio (ROS). Estudos indicaram que Eleutherine americana Merr contém profundas propriedades biológicas que protegem contra células cancerígenas, diminuição do nível de protrombina e vasoconstrição dos vasos. Será interessante estudar o efeito do extrato da planta em rins expostos ao acetato de chumbo. Este estudo teve como objetivo avaliar os efeitos nefroprotetores do extrato de Eleutherine americana Merr sobre a citotoxicidade do acetato de chumbo em camundongos BALB/c. Um total de 25 camundongos BALB/c foram divididos aleatoriamente em cinco grupos. O Grupo 1 recebeu 0,5% de Na-CMC por via oral, enquanto o Grupo 2 foi tratado por via oral com 0,075 g/kg de peso corporal de acetato de chumbo (Pb(CH3COO)2). Os grupos 3 a 5 receberam diferentes dosagens de Eleutherine americana Merr de 30, 60 e 120 mg/kg de peso corporal de acordo e simultaneamente com Pb(CH3COO)2. Todos os tratamentos foram de 35 dias. Os camundongos foram sacrificados após 35 dias, amostras de sangue foram coletadas para análise de creatinina e uréia enquanto os rins foram para estudos histológicos. Os níveis de creatinina e uréia foram significativamente maiores nos camundongos tratados com Pb(CH3COO)2 (p<0,05). O tratamento com o extrato da planta reduziu significativamente o nível de creatinina sanguínea e uréia sanguínea na concentração de extrato de 30mg/kg de peso corporal (p<0,05). Estudos histológicos dos rins mostraram que o Pb(CH3COO)2 causou atrofia glomerular e destruição tubular. O tratamento com o extrato da planta nas dosagens de 30 e 60 mg/kg de peso corpóreo pareceu melhorar o efeito do Pb(CH3COO)2 na estrutura dos néfrons. Extrato de Elutherine americana Merr demonstrou ter efeito nefroprotetor contra o ataque de Pb(CH3COO)2 em camundongos
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