Production of Antimicrobial Compounds using Thermophilic Bacteria Species Bacillus subtilis and Bacillus Tequilensis

Helmi Andriyani; Natacia Natacia; Edy Fachrial

doi:10.5935/jetia.v7i31.776

Autores

Helmi Andriyani Departamento de Farmácia Clínica, Faculdade de Medicina, Universitas Prima Indonésia http://orcid.org/0000-0001-5236-7232 (não autenticado)
Natacia Natacia Departamento de Farmácia Clínica, Faculdade de Medicina, Universitas Prima Indonésia http://orcid.org/0000-0001-8818-9511 (não autenticado)
Edy Fachrial Laboratório de Biologia Molecular, Faculdade de Medicina, Universitas Prima Indonésia http://orcid.org/0000-0002-5237-5803 (não autenticado)

DOI:

https://doi.org/10.5935/jetia.v7i31.776

Resumo

As infecções causadas por bactérias resistentes são um problema crescente de saúde pública, conseqüentemente, uma nova fonte de microrganismos que possam ser utilizados para a produção de antimicrobianos é necessária. Um dos microrganismos capazes de produzir antimicrobianos são as bactérias termofílicas, a saber B. subtilis e B. tequilensis. Devido ao fato de terem enzimas resistentes à temperatura quente, eles não são facilmente danificados. Portanto, este estudo visa a produção de novos antimicrobianos de B.subtilis e B.tequilensis. A atividade antimicrobiana foi observada em 5 isolados bacterianos termofílicos pelo método de difusão em disco. Os resultados mostraram que a zona de inibição mais forte (diâmetro do disco = 6 mm) ou atividade antimicrobiana contra S.aureus que foi classificada como gram-positiva foi descoberta em B.subtilis UTMP15 (10,27 mm) no tempo de incubação de 24 horas, e contra E .coli classificado como Gram-negativo, estava em B. Subtilis UTMP12 (8,59 mm) em 48 horas. Portanto, o isolado é um potencial agente antimicrobiano.

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