Isolation of Key Phytochemicals From Terminalia chebula Leaves and Evaluation of Its Immunomodulatory Potential

Resumen

This research work aims to identify and analyze bioactive constituents from the extract made from the leaves of Terminalia chebula using both computational and experimental approaches, with possible immune boosting and antiviral properties. For its broad pharmacological properties, including antibacterial, antiviral, antioxidant, anti-inflammatory, and immunomodulatory activities, Terminalia chebula is highly regarded and recognized. These medicinal potentials are ascribed to its abundant content of bioactive phytochemicals, including tannins, phenolics, flavonoids, glycosides, and sterpenoids. Due to the worldwide health crisis caused by infectious diseases like COVID-19, scientists are once again interested in studying plant-based substances to see if they might boost the immune system and fight viruses. In this light, T. chebula emerges as an interesting candidate for research owing to its historic medicinal significance and pharmacological diversity. The study uses Gas Chromatography–Mass Spectrometry (GC-MS) to identify compounds in detail and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling with Swiss ADME to check how well the identified molecules work as drugs and how similar they are to drugs. Then, molecular docking experiments are done on selected drugs with good ADME profiles. These studies focus on important immunological and viral proteins, like Interleukin-6 and a protein linked to COVID-19, to see how well they attach and how biologically important they might be.