Effectiveness of white guava leaves (Psidium guajava var. Pyrifera l.) In repair proximal tubule damage and glomerulus diameter in hyperglycemic mice
Abstract
Diabetes Mellitus (DM) is a global health problem with a high prevalence rate in Indonesia, ranking 5th out of 10 countries with the highest number of diabetes cases. In 2019, Indonesia had the highest prevalence rate of diabetes mellitus at 9.3% (463 million) and an estimated increase to 12.2% (783 million) by 2045. The kidney, the primary organ affected by high glucose levels, is the primary organ affected by a compound. Guava leaves, which contain alkaloids, flavonoids, saponins, polyphenols, tannins, and calcium, have been found to have anti-diabetic properties.This research aimed to investigate the effect of variations in the number of white guava leaves used in making waters tew on kidney histopathology in alloxan-induced mice (Mus musculus). The mice were divided into five groups, with initial blood glucose levels measured after being induced by alloxan and after treatment with white guava seeds. After treatment, kidney histopathological preparations were made using Hematoxylin Eosin (HE) staining. The results showed that the average size of the proximal tubule proximal and glomerular diameter was larger than the positive (+) control group. The average glomerular diameter at K0, P1, P2, and P3 was smaller than the positive (+) control. The results of the study suggest that boiled water from white guava leaves may have potential therapeutic benefits for diabetics.
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