High Sensitive 2D Photonic Crystal Biosensor Based on Hexagonal Resonator Coupled with a Capsule-Shaped for the Detection of Deferent Cancerous Cells

Hocine Bensalah; Wahiba Menasri; Abderrahmane Imam; Abdesselam Hocini; Mohammad Soroosh; Hocine Bahri; Hiba Bouandas; Imane Zegaar; Abdelhalim Tlemcani; Nadia Menasri

doi:10.5935/jetia.v12i59.3684

Authors

Hocine Bensalah Laboratory of Analyse of Signal and System, Electronics Department, University of M’Sila BP.166, Route Ichebilia, M’Sila, 28000, Algeria http://orcid.org/0000-0002-4442-8389 (unauthenticated)
Wahiba Menasri Renewable Energies and Materials Research Laboratory, Faculy of Technology, University Yahia Fares of Medea, 26000, Algeria Medea, Algeria http://orcid.org/0009-0005-5458-4173 (unauthenticated)
Abderrahmane Imam STIC laboratory Telecommunication departement University of Tlemcen Tlemcen, Algeria https://orcid.org/0000-0003-1250-8066 (unauthenticated)
Abdesselam Hocini Laboratory of Analyse of Signal and System, Electronics Department, University of M’Sila BP.166, Route Ichebilia, M’Sila, 28000, Algeria https://orcid.org/0000-0002-7602-6210 (unauthenticated)
Mohammad Soroosh Department of Electrical Engineering Shahid Chamran University of Ahvaz, Ahvaz, Iran https://orcid.org/0000-0003-1956-8272 (unauthenticated)
Hocine Bahri Interfaces of BioNanoSystems Institute of Materials in Electrical Engineering 1,RWTH Aachen University, Sommerfeldstraße 24, D -52074 Aachen, Germany https://orcid.org/0000-0003-0932-5533 (unauthenticated)
Hiba Bouandas Applied Optics Laboratory Institute of Optics and Precision Mechanics University Of Setif 1, Setif 19000, Algeria. https://orcid.org/0000-0003-1266-1546 (unauthenticated)
Imane Zegaar LIST Laboratory, University of M’Hamed Bougara Boumerdes, Avenue of Independence, 35000, Boumerdes, Algeria https://orcid.org/0000-0001-7073-8455 (unauthenticated)
Abdelhalim Tlemcani Electrical Engineering and Automation Research Laboratory (LREA), University of Medea, Medea, Algeria http://orcid.org/0000-0002-4385-671X (unauthenticated)
Nadia Menasri Faculty of Medicine, University Saad Dahlab Blida1, blida, Algeria http://orcid.org/0009-0001-5948-4455 (unauthenticated)

DOI:

https://doi.org/10.5935/jetia.v12i59.3684

Abstract

In the present study, we introduce an innovative photonic crystal architecture meticulously engineered for biomedical applications, particularly optimized for biosensing functionalities. Our study focuses on meeting the increasing demand for quick, reliable, and easy-to-use detection methods in medical diagnostics. The proposed architecture employs a hexagonal arrangement integrated with two waveguides for signal input and output, which is further augmented by the inclusion of a pill-shaped resonator to enhance sensitivity. The design enables strong confinement of the electromagnetic field and improves interaction with the analyte. The simulations were performed using the Finite-Difference Time-Domain (FDTD) method over a wavelength range of 1.6 to 1.95 micrometers (µm). The findings indicate that the biosensor is capable of attaining a peak sensitivity of 571 nanometers per refractive index unit (nm/RIU), thereby underscoring its significant potential for detecting subtle alterations in biological specimens and contributing to the advancement of medical diagnostics. Such sensitivity levels demonstrate the effectiveness of the proposed structure in identifying biomolecular interactions and refractive index variations typically associated with various types of cancer cells and other biological conditions.